PANS/PANDAS RESEARCH
The PPN Research Library is a comprehensive collection of published works related to PANDAS and PANS. The library includes the original published studies from the NIMH team that first reported on the PANDAS condition as well as the primary additional studies that followed. The library consists of summaries and select critiques, as well as the link and reference for each study.
Featured Research: Interferon-λ-neutralizing autoantibodies and common autoimmune disease autoantibodies in pediatric acute-onset neuropsychiatric syndrome
This study provides new evidence that a subset of children with PANS exhibit autoantibodies associated with established autoimmune diseases as well as functionally neutralizing antibodies against interferon lambda, further supporting immune dysregulation as a biological component of PANS. These findings expand current understanding of PANS pathophysiology and identify potential immune pathways that may inform future biomarker discovery and targeted therapeutic research.
Compilation of Research
Research on PANS and PANDAS has expanded significantly over the past years. Growing body of literature reflects increasing scientific attention across clinical, immunologic, and multidisciplinary care domains. Access a list of selected publications (2018–current) that highlight key contributions to this developing research landscape.
Archived Earlier Research Papers Organized by Category
- Clinical Presentation of PANDAS (and PANS)
- Relationship of Obsessive-Compulsive Disorder (OCD) to Sydenham Chorea (And Rheumatic Fever)
- Studies Of The Relationship Of Group A Strep (“GAS”) to OCD/PANDAS
- Laboratory Studies Of GABHS Serologic Markers
- Laboratory Studies of Cross-Reactive (Anti-GAS/Anti-Brain) Antibodies in Sydenham’s Chorea and PANDAS/PANS
- Animal Models of PANDAS
- Additional PANDAS Studies Including Treatment Trials
- Studies Of The Relationship of GABHS to Tic Disorders (Including Episodic Tic Disorders Labeled as PANDAS)
- Commentaries
- Bibliography
PANS Research Consortium Papers
Consensus Statement and consortium guidelines for evaluation and original articles:
https://www.pandasppn.org/jcap2015/
Treatment guidelines developed by the PANS/PANDAS Research Consortium are available in the 2017 Journal of Child and Adolescent Psychopharmacology:
https://www.pandasppn.org/jcap2017/