Research Library


The PPN Research Library is a comprehensive collection of published works related to PANDAS and PANS. The library includes the original published studies from the NIMH team that first reported on the PANDAS condition as well as the primary additional studies that followed. The library consists of a synopsis and critique of each study, as well as the link and reference for each study.

PANDAS IVIG Study Published

New IVIG study shows >60% mean reduction in symptoms for PANDAS patients.

A new paper submitted to the Journal of the American Academy of Child & Adolescent Psychiatry describes the outcome of the NIMH double-blind placebo controlled study of IVIG for treatment of symptoms in children who meet the criteria of PANDAS. While the study has many interesting findings, the most significant is that children who had prophylactic antibiotics followed by an open-label IVIG had a >60% mean reduction in CYBOCS score. These symptom improvements were sustained through follow up at 6 months.


Recent Publications

A Double-Blind Randomized Placebo-Controlled Pilot Study of Azithromycin in Youth with Acute-Onset Obsessive-Compulsive Disorder,
Murph,y TK et al, Journal of Child and Adolescent Psychopharmacology, 2017 Mar 30. doi: 10.1089/cap.2016.0190.  Read at

Improvement of psychiatric symptoms in youth following resolution of sinusitis,
Mahony, Talia et al., International Journal of Pediatric Otorhinolaryngology , Volume 92 , 38 – 44, January 2017. Read at:

Group A Streptococcus intranasal infection promotes CNS infiltration by streptococcal-specific Th17 cells,
Thamotharampillai Dileepan, et al.Published December 14, 2015, J Clin Invest. 2015. doi:10.1172/JCI80792.

Special issue of Journal of Child and Adolescent Psychopharmacology. February 2015, 25(1)

Introduction :
Special Issue on Pediatric Acute-Onset Neuropsychiatric Syndrome, Kiki Chang, Harold S Koplewicz, Ron Steingard

Consensus Statement :
Clinical Evaluation of Youth with Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS):
Recommendations from the 2013 PANS Consensus Conference
, Kiki Chang, Jennifer Frankovich, Michael Cooperstock, Madeleine W. Cunningham, M. Elizabeth Latimer, Tanya K. Murphy, Mark Pasternack, Margo Thienemann, Kyle Williams, Jolan Walter, Susan E. Swedo

Original Articles: