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RESEARCH LIBRARY

PANDAS PANS Research

The PPN Research Library is a comprehensive collection of published works related to PANDAS and PANS. The library includes the original published studies from the NIMH team that first reported on the PANDAS condition as well as the primary additional studies that followed. The library consists of a synopsis and critique of each study, as well as the link and reference for each study.

Antibodies From Children With PANDAS Bind Specifically to Striatal Cholinergic Interneurons and Alter Their Activity

“These findings provide strong evidence for striatal CINs as a critical cellular target that may contribute to pathophysiology in children with rapid-onset OCD symptoms, and perhaps in other conditions.”

Association of Pediatric Acute-Onset Neuropsychiatric Syndrome With Microstructural Differences in Brain Regions Detected via Diffusion-Weighted Magnetic Resonance Imaging

“In this case-control study of 34 consecutive patients with pediatric acute-onset neuropsychiatric syndrome who had 3 Tesla magnetic resonance imaging, all assessed brain regions, particularly the deep gray matter (eg, the thalamus, basal ganglia, and amygdala), had statistically significantly increased mean diffusivity compared with 64 control participants.”

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Recent Publications

Focus on Cardiologic Findings in 30 Children With PANS/PANDAS: An Italian Single-Center Observational Study
Murciano M, Biancone DM, Capata G, et al. Focus on Cardiologic Findings in 30 Children With PANS/PANDAS: An Italian Single-Center Observational Study. Front Pediatr. 2019;7:395. Published 2019 Oct 1. doi:10.3389/fped.2019.00395

Differential binding of antibodies in PANDAS patients to cholinergic interneurons in the striatum, Brain, Behavior, and Immunity, Luciana R. Frick, Maximiliano Rapanelli, Kantiya Jindachomthong, Paul Grant, James F. Leckman, Susan Swedo, Kyle Williams, Christopher Pittenger,Available online 9 December 2017, ISSN 0889-1591, https://doi.org/10.1016/j.bbi.2017.12.004.

Course of Neuropsychiatric Symptoms After Introduction and Removal of Nonsteroidal Anti-Inflammatory Drugs: A Pediatric Observational Study
Spartz Ellen J., Freeman G. Mark Jr., Brown Kayla, Farhadian Bahare, Thienemann Margo, and Frankovich Jennifer. Journal of Child and Adolescent Psychopharmacology. July 2017, ahead of print. https://doi.org/10.1089/cap.2016.0179

Effect of Early and Prophylactic Nonsteroidal Anti-Inflammatory Drugs on Flare Duration in Pediatric Acute-Onset Neuropsychiatric Syndrome: An Observational Study of Patients Followed by an Academic Community-Based Pediatric Acute-Onset Neuropsychiatric Syndrome Clinic
Brown Kayla D., Farmer Cristan, Freeman G. Mark Jr., Spartz Ellen J., Farhadian Bahare, Thienemann Margo, and Frankovich Jennifer. Journal of Child and Adolescent Psychopharmacology. July 2017, ahead of print. https://doi.org/10.1089/cap.2016.0193

Journal of Child and Adolescent Psychopharmacology. July 2017

Introduction:
Overview of Treatment of Pediatric Acute-Onset Neuropsychiatric Syndrome, Swedo Susan E., Frankovich Jennifer, and Murphy Tanya K.

Articles Addressing Clinical Management of PANS:

Special issue of Journal of Child and Adolescent Psychopharmacology. February 2015, 25(1)

Introduction :
Special Issue on Pediatric Acute-Onset Neuropsychiatric Syndrome, Kiki Chang, Harold S Koplewicz, Ron Steingard

Consensus Statement :
Clinical Evaluation of Youth with Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS):Recommendations from the 2013 PANS Consensus Conference , Kiki Chang, Jennifer Frankovich, Michael Cooperstock, Madeleine W. Cunningham, M. Elizabeth Latimer, Tanya K. Murphy, Mark Pasternack, Margo Thienemann, Kyle Williams, Jolan Walter, Susan E. Swedo

Original Articles: