The PPN Research Library is a comprehensive collection of published works related to PANDAS and PANS. The library includes the original published studies from the NIMH team that first reported on the PANDAS condition as well as the primary additional studies that followed. The library consists of a synopsis and critique of each study, as well as the link and reference for each study.

PANDAS IVIG Study Published

New IVIG study shows >60% mean reduction in symptoms for PANDAS patients.

A new paper submitted to the Journal of the American Academy of Child & Adolescent Psychiatry describes the outcome of the NIMH double-blind placebo controlled study of IVIG for treatment of symptoms in children who meet the criteria of PANDAS. While the study has many interesting findings, the most significant is that children who had prophylactic antibiotics followed by an open-label IVIG had a >60% mean reduction in CYBOCS score. These symptom improvements were sustained through follow up at 6 months.


Recent Publications

Differential binding of antibodies in PANDAS patients to cholinergic interneurons in the striatum, Brain, Behavior, and Immunity, Luciana R. Frick, Maximiliano Rapanelli, Kantiya Jindachomthong, Paul Grant, James F. Leckman, Susan Swedo, Kyle Williams, Christopher Pittenger,Available online 9 December 2017, ISSN 0889-1591,

Course of Neuropsychiatric Symptoms After Introduction and Removal of Nonsteroidal Anti-Inflammatory Drugs: A Pediatric Observational Study
Spartz Ellen J., Freeman G. Mark Jr., Brown Kayla, Farhadian Bahare, Thienemann Margo, and Frankovich Jennifer. Journal of Child and Adolescent Psychopharmacology. July 2017, ahead of print.

Effect of Early and Prophylactic Nonsteroidal Anti-Inflammatory Drugs on Flare Duration in Pediatric Acute-Onset Neuropsychiatric Syndrome: An Observational Study of Patients Followed by an Academic Community-Based Pediatric Acute-Onset Neuropsychiatric Syndrome Clinic
Brown Kayla D., Farmer Cristan, Freeman G. Mark Jr., Spartz Ellen J., Farhadian Bahare, Thienemann Margo, and Frankovich Jennifer. Journal of Child and Adolescent Psychopharmacology. July 2017, ahead of print.

Journal of Child and Adolescent Psychopharmacology. July 2017

Overview of Treatment of Pediatric Acute-Onset Neuropsychiatric Syndrome, Swedo Susan E., Frankovich Jennifer, and Murphy Tanya K.

Articles Addressing Clinical Management of PANS:

Special issue of Journal of Child and Adolescent Psychopharmacology. February 2015, 25(1)

Introduction :
Special Issue on Pediatric Acute-Onset Neuropsychiatric Syndrome, Kiki Chang, Harold S Koplewicz, Ron Steingard

Consensus Statement :
Clinical Evaluation of Youth with Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS):Recommendations from the 2013 PANS Consensus Conference , Kiki Chang, Jennifer Frankovich, Michael Cooperstock, Madeleine W. Cunningham, M. Elizabeth Latimer, Tanya K. Murphy, Mark Pasternack, Margo Thienemann, Kyle Williams, Jolan Walter, Susan E. Swedo

Original Articles: