PANS/PANDAS: Lab Testing
PANS/PANDAS is a clinical diagnosis. Laboratory testing may determine an infectious trigger, rule out other diagnoses, and aid in the development of a treatment plan. Refer to the diagnostic flowchart for additional guidance in evaluating patients and lab test considerations for PANS and PANDAS.
Initial testing
- Strep A rapid test and throat culture
- If negative, check ASO and AntiD-Nase-B
- CBC with differential to check for other infections
- Perianal strep swab, if indicated
- Anti-nuclear antibodies
- Quantitative immunoglobins (IgG, IgA, IgM, IgE) with IgG subclasses
- Urinalysis to assess hydration and rule out UTI when urinary complaints are present
Additional considerations depending on presentation and symptom severity:
- ENT referral for tonsil and adenoid evaluation
- Cunningham Panel™
- MRI and EEG study
- Sleep study to evaluate sleep disturbances
- Swallowing study to evaluate possible cause for restrictive eating
- Lumbar puncture