The Role of Adaptive Immunity and Genetic Risk Factors in Vascular and Neuronal Dysfunction in Post-Infectious Autoimmune Encephalitis
Presented by Dritan Agalliu, Ph.D.
Associate Professor, Departments of Neurology, Pathology and Cell Biology, Columbia University Irving Medical Center
Physicians, nurse practitioners, physician assistants, nurses, and therapists.
Participants will be able to:
- Evaluate the causes of Autoimmune Encephalitis, Post-Infectious Autoimmune Encephalitis and the immune mechanisms that induce the disease.
- Determine how Th17 lymphocytes induce blood-brain barrier damage, neuroinflammation and cause neuronal impairment in animal models for post-infectious basal ganglia encephalitis.
- Review the cytokines that are present in sera from PANDAS/PANS patients and their effect on the blood-brain barrier in vitro.
- Consider the genetic risk factors identified in PANDAS/PANS that predispose the children to develop the disease and incorporate a team-based approach to counsel and guide patients and families diagnosed with PANDAS/PANS.
Estimated Time for Completion: 60 minutes
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