PANS/PANDAS Research and Resources:
A Compilation of Studies and Articles (2018-2025)
PANDAS Physicians Network is a leading authority for information pertaining to PANS and PANDAS. By providing the most up to date research, case studies, and scholarly articles on these conditions, physicians and other providers can be confident in the diagnostic and treatment resources PPN provides.
2025
- RESEARCH REPORT: Defining clinical course of patients evaluated for pediatric acute-onset neuropsychiatric syndrome (PANS): phenotypic classification based on 10 years of clinical data (2025)
- RESEARCH REPORT: Neurological Soft Signs at Presentation in Patients With Pediatric Acute-Onset Neuropsychiatric Syndrome (2025)
- RESEARCH REPORT: Obsessive Compulsive Disorder associated with Autoimmunity in Youth: Clinical Course before and after Immunomodulation (2025)
- RESEARCH REPORT: Pediatric Neuropsychiatric Syndromes: Updates on COVID-19 Infection and Vaccination (2025)
- RESEARCH REPORT: Occupational performance patterns in children with paediatric acute-onset neuropsychiatric syndrome (2025)
- RESEARCH REPORT: Relationships between sensory reactivity and occupational performance in children with paediatric acute-onset neuropsychiatric syndrome (2025)
- RESEARCH REPORT: Parent perceptions of various treatment approaches for PANS and PANDAS (2025)
- RESEARCH REPORT:IL-17 in serum and cerebrospinal fluid of pediatric patients with acute neuropsychiatric disorders: Implications for PANDAS and PANS (2024)
- CASE SERIES: New-onset OCD and juvenile enthesitis related arthritis after COVID-19 (Three Cases) (2025)
- CASE SERIES: Abrupt onset or exacerbation of anorexia nervosa following recent infections: a mini-review and a case report with an atypical manifestation of PANS (2025)
- CASE SERIES: Eight cases of Pediatric Acute Onset Neuropsychiatric Syndrome (PANS) with Inflammatory Bowel Disease (IBD): Immunologic Intersections (2025)
2024
- SCHOLARLY ARTICLE: Streptococcus pyogenes: Basic Biology to Clinical Manifestations (2024)
- RESEARCH REPORT: Developmental Impacts of PANS/PANDAS and Inadequate Support for Children and Families (2024)
- RESEARCH REPORT: Dopamine receptor autoantibody signaling in infectious sequelae differentiates movement versus neuropsychiatric disorders (2024)
- RESEARCH REPORT: The COVID-19 pandemic and children with PANS/PANDAS: an evaluation of symptom severity, telehealth, and vaccination hesitancy (2024)
- RESEARCH REPORT: REM sleep atonia in patients with pediatric acute-onset neuropsychiatric syndrome (PANS): implications for pathophysiology (2024)
- RESEARCH REPORT: The Flip Side of the Coin Giftedness in Pediatric Acute-Onset Neuropsychiatric Syndrome (2024)
- RESEARCH REPORT: Reliability and validity of a newly developed PANDAS/PANS questionnaire (2024)
- RESEARCH REPORT: IVIG response in pediatric acute- onset neuropsychiatric syndrome correlates with reduction in pro- inflammatory monocytes and neuropsychiatric measures (2024)
- RESEARCH REPORT: Cerebrospinal fluid characteristics of patients presenting for evaluation of pediatric acute-neuropsychiatric syndrome (2024)
- RESEARCH REPORT: Elevated antibody binding to striatal cholinergic interneurons in patients with pediatric acute-onset neuropsychiatric syndrome (2024)
- RESEARCH REPORT: Development of Autoimmune Diseases Among Children With Pediatric Acute-Onset Neuropsychiatric Syndrome (2024)
- RESEARCH REPORT: Immunological characterization of an Italian PANDAS cohort (2024)
- RESEARCH REPORT: Folate Receptor Alpha Autoantibodies in the Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS) and Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS) Population (2024)
- RESEARCH REPORT: Psychometric Properties of the PANS 31-Item Symptom Rating Scale (2024)
- REVIEW ARTICLE: Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS) and Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS): Immunological Features Underpinning Controversial Entities (2024)
- COMMENTARY: Strep Throat and the Backstory for PANS and PANDAS (2024)
- CASE REPORT: Diagnosing and Treating Pediatric Autoimmune Neuropsychiatric Disorder Associated With Streptococcal Infections (2024)
- CASE REPORT: Narcolepsy and pediatric acute-onset neuropsychiatric syndrome: A case report that suggests a putative link between the two disorders (2024)
- CASE REPORT: PANDAS, a series of difficult decisions: a case report (2024)
2023
- RESEARCH REPORT: Intravenous immunoglobulin treatment improves multiple neuropsychiatric outcomes in patients with pediatric acute-onset neuropsychiatric syndrome (2023)
- RESEARCH REPORT: Distinct Th17 effector cytokines differentially promote microglial and blood-brain barrier inflammatory responses during post-infectious encephalitis (2023)
- REVIEW PAPER: Neuroinflammation in Obsessive-Compulsive Disorder: Sydenham Chorea, Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections, and Pediatric Acute Onset Neuropsychiatric Syndrome (2023)
- REVIEW PAPER: An updated review of pediatric autoimmune neuropsychiatric disorders associated with Streptococcus/pediatric acute-onset neuropsychiatric syndrome, also known as idiopathic autoimmune encephalitis: What the allergist should know (2023)
- REVIEW PAPER: Postinfectious Inflammation, Autoimmunity, and Obsessive-Compulsive Disorder: Sydenham Chorea, Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal Infection, and Pediatric Acute-Onset Neuropsychiatric Disorder (2023)
- CASE SERIES: Arthritis in Children with Psychiatric Deteriorations: A Case Series (2023)
- CASE STUDY: Clinicopathologic Characteristics of PANDAS in a Young Adult: A Case Report (2024)
2022
- RESEARCH REPORT: Children With PANS May Manifest POTS (2022)
- RESEARCH REPORT: Therapeutic plasma exchange in adolescent and adult patients with autoimmune neuropsychiatric disorders associated with streptococcal infections (2022)
- RESEARCH REPORT: Paediatric Acute-onset Neuropsychiatric Syndrome (PANS) and intravenous immunoglobulin (IVIG): comprehensive open-label trial in ten children (2022)
- RESEARCH REPORT: Prevalence of pediatric acute-onset neuropsychiatric syndrome PANS in children and adolescents with eating disorders (2022)
- RESEARCH REPORT: A Survey of Demographics, Symptom Course, Family History, and Barriers to Treatment in Children with Pediatric Acute-Onset Neuropsychiatric Disorders and Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal Infections (2022)
- RESEARCH REPORT: Metabolomic Characterization of Pediatric Acute-Onset Neuropsychiatric Syndrome (2021)
- CASE STUDY: SARS-CoV-2/COVID-19 associated pediatric acute-onset neuropsychiatric syndrome a case report of female twin adolescents (2022)
- CASE STUDY: PANS-PANDAS, case report (2022)
2021
- RESEARCH REPORT: Artificial Neural Networks Analysis of polysomnographic and clinical features in PANS: from sleep alteration to “Brain Fog” (2021)
- RESEARCH REPORT: Cognitive, Graphomotor, and Psychosocial Challenges in Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infections (2021)
- RESEARCH REPORT: Evaluation of Intravenous Immunoglobulin in PANS (2021)
- RESEARCH REPORT: Role of tonsillectomy and adenoidectomy in parental satisfaction of treatments for PANDAS (2021)
- RESEARCH REPORT: The Impact of the COVID-19 Epidemic During the Lockdown on Children With the Pediatric Acute-Onset Neuropsychiatric Syndrome (PANDAS/PANS): The Importance of Environmental Factors on Clinical Conditions (2021)
- RESEARCH REPORT: Treatment Barriers in PANS/PANDAS: Observations from Eleven Healthcare (2021)Provider Families (2021)
- RESEARCH REPORT: Group A streptococcal antigen exposed rat model to investigate neurobehavioral and cardiac complications associated with post‐streptococcal autoimmune sequelae (2021)
- RESEARCH REPORT: Patients with abrupt early-onset OCD due to PANS tolerate lower doses of antidepressants and antipsychotics (2021)
2020
- RESEARCH REPORT: Association of Pediatric Acute-Onset Neuropsychiatric Syndrome With Microstructural Differences in Brain Regions Detected via Diffusion-Weighted Magnetic Resonance Imaging (2020)
- RESEARCH REPORT: PANS/PANDAS: Clinical Experience in IVIG Treatment and State of the Art in Rehabilitation Approaches (2020)
- RESEARCH REPORT: Antibodies From Children With PANDAS Bind Specifically to Striatal Cholinergic Interneurons and Alter Their Activity (2020)
- RESEARCH REPORT: Autoantibody Biomarkers for Basal Ganglia Encephalitis in Sydenham Chorea and Pediatric Autoimmune Neuropsychiatric Disorder Associated With Streptococcal Infections (2020)
- RESEARCH REPORT: Th17 lymphocytes drive vascular and neuronal deficits in a mouse model of postinfectious autoimmune encephalitis (2020)
- CASE SERIES: Severe Psychotic Symptoms in Youth with PANS/PANDAS: Case-Series (2020)
2019
- RESEARCH REPORT: Focus on Cardiologic Findings in 30 Children With PANS/PANDAS: An Italian Single-Center Observational Study (2019)
- RESEARCH REPORT: Evaluation of the Cunningham Panel™ in pediatric autoimmune neuropsychiatric disorder associated with streptococcal infection (PANDAS) and pediatric acute-onset neuropsychiatric syndrome (PANS): Changes in antineuronal antibody titers parallel changes in patient symptoms (2019)
- RESEARCH REPORT: Bidirectional relationship between eating disorders and autoimmune diseases (2019)
- RESEARCH REPORT: Brain-Immune Alterations and Mitochondrial Dysfunctions in a Mouse Model of Paediatric Autoimmune Disorder Associated with Streptococcus: Exacerbation by Chronic Psychosocial Stress (2019)
- RESEARCH REPORT: Psychotic symptoms in youth with Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) may reflect syndrome severity and heterogeneity (2019)
- CASE STUDY: Neuropsychiatric symptoms following sore throat in a young boy (2019)
2018
- RESEARCH REPORT: Differential binding of antibodies in PANDAS patients to cholinergic interneurons in the striatum (2018)
- RESEARCH REPORT: The Burden of Caring for a Child or Adolescent With Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS): An Observational Longitudinal Study (2018)
- REVIEW PAPER: Treatment of PANDAS and PANS: a systematic review (2018)
- CASE STUDY: Altered cerebral glucose metabolism normalized in a patient with a pediatric autoimmune neuropsychiatric disorder after streptococcal infection (PANDAS)-like condition following treatment with plasmapheresis: a case report (2018)
For additional research, visit the PPN research library at pandasppn.org/research.
Research-Based Resources for Pediatricians and Clinicians
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