Video: Dr. Jennifer Frankovich Discusses PANS/PANDAS
Post Infectious Inflammatory Brain Disorders and PANS/PANDAS:
A Conversation with Jennifer Frankovich, MD, MS
Clinical Professor in the Department of Pediatrics, Division of Allergy, Immunology Rheumatology at Stanford University/Lucile Packard Children’s Hospital. Co-director of Stanford’s Immune Behavioral Health Clinic and a founding member of the PANS Research Consortium.
Hosted by Keith Moore, PANDAS Physicians Network, Director of Research
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PANDAS Physicians Network 2022
Discussion Topics Include:
✓ Is PANS auto-immune or more an inflammatory disorder
✓ What is the role of inflammation on neuropsychiatric symptoms
✓ What are potential immunogenic markers associated with PANS
✓ Research vs clinical treatment – classifying the acuteness of symptom onset
✓ Impact of COVID-19 on neuropsychiatric disorders
✓ Relevance of the microbiome and the gut-brain link
✓ Participation in the new PANS/PANDAS IVIG trial
✓ Building a biorepository and the need for healthy controls
Resources:
- Murphy TK, Snider LA, Mutch PJ, Harden E, Zaytoun A, Edge PJ, Storch EA, Yang MC, Mann G, Goodman WK, Swedo SE. Relationship of movements and behaviors to Group A Streptococcus infections in elementary school children. Biol Psychiatry. 2007 Feb 1;61(3):279-84. doi: 10.1016/j.biopsych.2006.08.031. Epub 2006 Nov 27. PMID: 17126304.
- Yaddanapudi, K., Hornig, M., Serge, R. et al. Passive transfer of streptococcus-induced antibodies reproduces behavioral disturbances in a mouse model of pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection. Mol Psychiatry 15, 712–726 (2010). https://doi.org/10.1038/mp.2009.77
- Dileepan, T., Smith, E. D., Knowland, D., Hsu, M., Platt, M., Bittner-Eddy, P., Cohen, B., Southern, P., Latimer, E., Harley, E., Agalliu, D., & Cleary, P. P. (2016, January 4). Group A Streptococcus intranasal infection promotes CNS infiltration by streptococcal-specific Th17 cells. The Journal of Clinical Investigation. Retrieved February 14, 2022, from https://www.jci.org/articles/view/80792
- Platt, M. P., Bolding, K. A., Wayne, C. R., Chaudhry, S., Cutforth, T., Franks, K. M., & Agalliu, D. (2020, March 24). Th17 lymphocytes drive vascular and neuronal deficits in a mouse model of postinfectious autoimmune encephalitis. PNAS. Retrieved February 14, 2022, from https://www.pnas.org/content/117/12/6708
- Quagliariello A, Del Chierico F, Russo A, Reddel S, Conte G, Lopetuso LR, Ianiro G, Dallapiccola B, Cardona F, Gasbarrini A and Putignani L (2018) Gut Microbiota Profiling and Gut–Brain Crosstalk in Children Affected by Pediatric Acute-Onset Neuropsychiatric Syndrome and Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infections. Front. Microbiol. 9:675. doi: 10.3389/fmicb.2018.00675.