NSAID Study Recruiting Participants

Massachusetts General Hospital and lead investigator, Kyle A Williams, MD, PhD, Director, Pediatric Neuropsychiatry and Immunology Program, Massachusetts General Hospital, are seeking participants for a study to evaluate the treatment effect of a NSAID (Nonsteroidal Anti-Inflammatory Drug) on PANDAS symptoms. The study will advance the understanding of effective treatments for children suffering from PANDAS.

Brief Summary:
This project aims to rigorously evaluate a potential treatment for inflammation-related Obsessive-Compulsive Disorder (OCD) symptoms in children. To accomplish this goal, the investigators will conduct a double-blind, randomized, placebo-controlled trial of Naproxen Sodium, a nonsteroidal anti-inflammatory drug (NSAID) in participants diagnosed with Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal infections (PANDAS).

This research fills a gap in the empirical evidence base for the treatment of PANDAS, and will add to a growing literature of empirically-derived practices for PANDAS.

To view the fill criteria and exclusions, please visit the clinical trials page at https://www.clinicaltrials.gov/ct2/show/NCT04015596.