Dritan Agalliu, PhD
Columbia University – Associate Professor of Pathology and Cell Biology (in Neurology)
ON DEMAND WEBINAR:
How Peripheral Infection Triggers Brain Inflammation
The 90 minutes webinar includes a presentation followed by a Q and A.
Looking at the Brains of PANDAS/PANS Children: How Peripheral Infection Triggers Brain Inflammation discusses:
- Molecular atlas of transciptome changes impacting the Blood Brain Barrier (BBB)
- Cytokine profiles of children sick with acute onset PANDAS/PANS
- IL17A and GM-CSF impact the BBB and microglia of the brain
Read the research discussed in the presentation HERE.
Questions answered in Q and A include:
- Based on this work is PANDAS / PANS an autoimmune disease or an inflammatory disorder?
- Do you have putative biomarkers that may aid diagnosis and/or responsiveness to treatment in PANDAS / PANS?
- How do elevated lab values of various cytokines / interleukins play into treatment decisions and diagnoses for PANDAS / PANS?
Click arrow to begin.
PUBLISHED RESEARCH (PANS/PANDAS)
Distinct Th17 effector cytokines differentially promote microglial and blood-brain barrier inflammatory responses during post-infectious encephalitis
Charlotte R. Wayne, Luca Bremner, Travis E. Faust, Violeta Durán-Laforet, Nicole Ampatey, Sarah J. Ho, Philip A. Feinberg, Panos Arvanitis, Bogoljub Ciric, Shannon L. Delaney, Wendy Vargas-Deming, Susan Swedo, Vilas Menon, Dorothy P. Schafer, Tyler Cutforth, Dritan Agalliu
bioRxiv 2023.03.10.532135; doi: https://doi.org/10.1101/2023.03.10.532135
Th17 lymphocytes drive vascular and neuronal deficits in a mouse model of postinfectious autoimmune encephalitis
Maryann P. Platt, Kevin A. Bolding, Charlotte R. Wayne, Sarah Chaudhry, Tyler Cutforth, Kevin M. Franks, Dritan Agalliu
Proceedings of the National Academy of Sciences Mar 2020, 117 (12) 6708-6716; DOI: 10.1073/pnas.1911097117
Hello from the Other Side: How Autoantibodies Circumvent the Blood-Brain Barrier in Autoimmune Encephalitis
Platt MP, Agalliu D, Cutforth T. Hello from the Other Side: How Autoantibodies Circumvent the Blood-Brain Barrier in Autoimmune Encephalitis. Front Immunol. 2017;8:442. Published 2017 Apr 21. doi:10.3389/fimmu.2017.00442
CNS autoimmune disease after Streptococcus pyogenes infections: animal models, cellular mechanisms and genetic factors
Cutforth T, DeMille MM, Agalliu I, Agalliu D. CNS autoimmune disease after Streptococcus pyogenes infections: animal models, cellular mechanisms and genetic factors. Future Neurol. 2016;11(1):63-76. doi:10.2217/fnl.16.4
Group A Streptococcus intranasal infection promotes CNS infiltration by streptococcal-specific Th17 cells
Thamotharampillai Dileepan1, Erica D. Smith2, Daniel Knowland2, Martin Hsu2, Maryann Platt3, Peter Bittner-Eddy1, Brenda Cohen1, Peter Southern1, Elizabeth Latimer4, Earl Harley5, Dritan Agalliu2,3, and P. Patrick Cleary1
Published December 14, 2015. J Clin Invest. 2015. doi:10.1172/JCI80792.
INTERVIEWS AND VIDEOS
Short summary video illustrating the findings of the Agalliu lab.